When the Great Plague of 1665 hit, a fifth of people in London died, with victims shut in their homes and a red cross painted on the door with the words 'Lord have mercy upon us'. The Black Death of 1348 famously killed half of the people in London within 18 months, with bodies piled five-deep in mass graves. The disease continues to affect populations around the world today. The plague, caused by the bacterium Yersinia pestis, was the cause of some of the world's deadliest pandemics, including the Justinian Plague, the Black Death, and the major epidemics that swept through China in the late 1800s.
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